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Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes

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Enhanced DNA repair and reduced apoptosis in the resistant cells were further demonstrated by the subdued expression of -H2AX and Cleaved-caspase 3, following cisplatin treatment, compared to the pronounced responses in the parent cells (Fig

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Indeed, Gpx1 - /- mice showed an alteration in neutrophil migration efficiency during inflammation

Not only that, higher blood glucose levels in type 2 diabetes are inversely correlated with serum osteocalcin levels (56)